20 January, 2012
Volume 148, Issue 1
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Volume 148, Issue 1
On the cover: In this issue of Cell, Tachibana et al. (pp. 285–295) assess the developmental potential of rhesus macaque pluripotent and totipotent stem cells by chimera assay. They find that pluripotent embryonic stem cells and cells from isolated inner cell masses do not contribute to chimeras. Rather, aggregation of totipotent early embryos was required. The cover image shows “Roku,” a chimeric monkey produced by embryo aggregation.
Coming February 2nd
- » A Gateway for MS
- » Resveratrol Replacements?
- » Personalized TB Therapy
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Bioactive Lysophospholipids
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Issue Highlights
ANALYSIS
As the global economic crisis deepens, is the long-term future of publicly funded research at risk?
Article by Macilwain
RESEARCH
Chromothripsis: the p53 Connection
One year on from the discovery of catastrophically damaged cancer chromosomes, clues emerge as to their origins.
Article by Korbel et al.
Minireview by Maher and Wilson
RESEARCH
Can monkey ESCs incorporate into host embryos and develop into chimeras? The situation in primates looks a bit more complex than in mice.
Article by Mitalipov et al.
Preview by Trounson and Grieshammer
RESEARCH
Executing the Necrosis Program
A small-molecule inhibitor of programmed necrosis reveals how RIP kinase fragments mitochondria.
Articles by Wang et al. and Wang et al.
Preview by Baehrecke and Chan
RESEARCH
Pancreatic Cancer Makes an Early Getaway
Metastasis can occur before detectable tumors form, but models of this rapid spread suggest improved treatment options.
Articles by Stanger et al. and Michor et al.
Preview by Tuveson
RESEARCH
Ordered firing of DNA replication origins depends on their clustering by Forkhead transcription factors.
Article by Aparicio et al.
Online Now
Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory
Amitabha Majumdar, Wanda Colón Cesario, Erica White-Grindley, Huoqing Jiang, Fengzhen Ren, Mohammed "Repon" Khan, Liying Li, Edward Man-Lik Choi, Kasthuri Kannan, Fengli Guo, Jay Unruh, Brian Slaughter, and Kausik Si
Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome
Tom Sexton, Eitan Yaffe, Ephraim Kenigsberg, Frédéric Bantignies, Benjamin Leblanc, Michael Hoichman, Hugues Parrinello, Amos Tanay, and Giacomo Cavalli
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Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock |
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